| ncRNA name | Chi3l1 siRNA |
| ncRNA Category | siRNA |
| Disease name | fungal keratitis |
| Species | Mus musculus |
| Tissues/Cell_line | corneas |
| Methods | ELISA, qPCR, immunohistochemistry, siRNA transfection |
| Expression pattern | associated |
| Functional description | While C. albicans keratitis was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly ameliorated keratitis, reduced fungal load, and decreased polymorphonucleocyte (PMN) infiltration in an interleukin 13 receptor α2 (IL-13Rα2)-dependent manner. |
| PubMed ID | 26238714 |
| Year | 2015 |
| Title | Chitinase 3-Like 1 Promotes Candida albicans Killing and Preserves Corneal Structure and Function by Controlling Host Antifungal Responses. |
| Drug-related ncRNA | NO |
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